Patients say psilocybin offers “experiencing everything” in contrast to the ennui of SSRIs

Depression is a problem. One is six Brits are prescribed drugs to counter it. But still nobody knows what it is, how it works, or how to cure it. 

This is in stark contrast to the popular narrative that ‘depression is caused by an imbalance of ‘“happiness chemical” serotonin in the brain’. The most popularly-prescribed anti-depressants ‘selective serotonin re-uptake inhibitors’ or SSRIs regulated it. Apparently. Like you might conclude by the name ‘selective’ and ‘serotonin’. Or by reading research in respected medical journal The Lancet, written by senior psychologists at Oxford and Yale; although the average depressive is more likely to get the mis-info off commercial content blogs from psychiatrists. 

SSRIs have some worrying side-effects. Like nasty poos, even worse sleep, plus most notoriously loss of libido – which is no good if your relationship is already on the rocks because of your depression. Or your redundancy, which is a major cause of depression but not taken into account by the medical sector. Plus, the ‘medical model’ actually makes patients feel more stigma around their depression than otherwise.

SSRI users report an ‘emotional numbness’ known medically as ‘SSRI-induced indifference’ with practical effects not dissimilar to depression itself. ‘Evidence indicates that a reduction in depressive symptoms may not be the single most important outcome to patients, but rather factors such as the ability to participate in everyday activities and return to work,’ says this British Medical Journal article from its 2020 Evidence Based Medicine special issue.

“It was like the light switch being turned on in a dark house… [my] concrete coat had come off”

But SSRIs do increase serotonin levels (like recreational ecstasy) although possibly reduce them long term (like recreational ecstasy). Plus – anecdotally – my close friends who are prescribed SSRIs do say “help take the edge off.” I wouldn’t want to go without my ADHD meds, which do make an enormous difference. But neither SSRIs nor my Amfexa go any way towards curing the conditions, only reducing symptoms.

A balls-out report from UCL published only this summer, made headlines by highlighting the gap between this narrative and reality. And we know what happens when anybody does that. (Like I’m fond of quoting, in the original version of The Emperor’s New Clothes the child who points out the emperor is naked is banished to the wilderness. Not made king instead by a grateful populace, which is a modern alteration). 

The status quo brought out its big guns. Rolling Stone, once the organ of the counter-culture, spread muck all over author Professor Joanna Moncrieff (of University College London, one of the most respected medical research centres in the world, while Rolling Stone is no longer respected as a pop music magazine, just saying) pointing out her membership of the Critical Psychiatry Network ‘Which aims to “[mount] a scientific challenge to claims about the nature and causes of mental disorder and the effects of psychiatric interventions.” Like RD Laing. Rolling Stone also drew attention to, and those of a sensitive disposition please stop reading now, her reticence for… vaccine mandates, as expressed in an open letter to the British Medical Journal from NHS workers that she signed. The real problem was that some of the shrill left’s enemies on the shrill right, like Fox News rabble-rouser Tucker Carlson, agreed with the paper. 

I’ll stop before I get depressed. The point is: psychedelic treatment for depression counters the ‘emotional numbness’ of the condition, on or off SSRIs.

In fact, the opposite happens. “It was like the light switch being turned on in a dark house, the concrete coat had come off,” said one PsiloDep Trial participant according to the vital presentation by Ashleigh Murphy-Beiner, a psychologist on the trials and facilitator of its dedicated ongoing integration circle. Another trial patient said: “I allow myself to experience everything, even if it's sadness. Now I know how to deal with my feelings rather than rather than repress them.”

Why? “Oceanic boundlessness” AKA increased connectivity, the mystical trip accompanied by profound meaning, “going beyond the self”, and resolution of emotions (it’s usually shame according to Murphy-Beiner) by mini-spiritual emergency-cum-challenging experience are the top signifiers. This is before we discuss the default mode network, neuroplasticity, or neurogenesis. The ‘inner healer’ or ‘homeostasis principle’ to use its new scientific name dispenses these as required.

If depression can be cured by restoring powerful human instincts like connection and meaning, is it caused by a lack of them? Former narrative cheerleader yet admittedly rather good writer Johann Hari made his comeback from exile with Lost Connections: Uncovering the Real Causes of Depression – and the Unexpected Solutions (here’s the TED Talk). Therein he claimed, backed up by doctors and patients, that depression is mostly caused by our bureaucratic dystopia: “the depression of many of my friends, even those in fancy jobs – who spend most of their waking hours feeling controlled and unappreciated – started to look not like a problem with their brains, but a problem with their environments,” he writes. And well done him. Although depression is not my area, and I’m far from qualified  as a pro, it’s very tempting to agree.

But if the problem isn’t brain chemistry but civilisation itself, isn’t sending depressives back out after psychedelic treatment into the same desperate non-life that made them so desperate in the first place just going to make them depressed again? At this point one can only make a fart joke, and nobody can get away with that better than proper brain box Dr Chris Timmerman, who tweeted this new report Understanding the effects of serotonin in the brain through its role in the gastrointestinal tract because it describes psychedelics as ‘cognitive laxatives’.